Current studies
Current studies
Here you will find details of some current research being carried out at North London NHS Foundation Trust.
To take part in any of the studies, or to find out more information please contact beh-tr.research@nhs.net or nlft.researchteam@nhs.net
MoRe (Mood Research) clinic
The MoRe (Mood Research) clinic is a North London NHS Foundation Trust research focussed clinic, funded by the Mental Health Translational Research Collaborative Mission (MH-TRC).
The MoRe clinic provides an initial assessment outlining treatment advice and research opportunities for service users with mood disorders, such as difficult-to-treat depression and bipolar disorder.
We are a non-emergency service. If you need an urgent response, we would advise using the urgent help page which can guide you to appropriate service or links for immediate or urgent help.
Who can be referred?
We accept referrals from individuals who are over 18 and who live in the Barnet, Camden Enfield, Haringey or Islington Boroughs. Service users must have a primary diagnosis of a current depressive episode of either unipolar or bipolar depression and are willing to consider being enrolled in research studies. The current depressive episode must be difficult to treat i.e. there has been no response to 2 or more treatment trials in the current episode of illness.
How to access this service
You can be referred to our service by your GP or another mental health treatment provider. Please download the referral form and send to charlotte.mair2@nhs.net.
Once a patient has been referred to the MoRe clinic, referrals will be reviewed and discussed by a multidisciplinary team. We may need more information to see if the clinic is appropriate. If this is the case, a member of the team will contact the patient to complete a screening assessment. If at the end of this assessment the patient meets the criteria for the clinic, the referral will be accepted and a time will be arranged to be assessed by one of the clinic doctors. If the referral is declined, the patient will be signposted to alternative sources of help as appropriate.
What to expect
Once a referral is accepted, assessments will encompass a formal structured clinical interview, review of past treatments during current episodes, observer-rated questionnaires and self-rated questionnaires. Depending on capacity further assessments may be taken, such as computerized assessments and neuroimaging (electroencephalography).
Once the assessment has finished, the clinician will write up an assessment letter and provide to the GP. The assessment letter will outline key results from the assessment and will include; diagnosis, comparison of past treatment to guidelines, relevant self- and observer-rating results and advice for further treatments and signposting.
After this, the patient will be discharged from the clinic and ongoing care will only be provided through and in the context of a research study.
Anxiety and Depression Research
CBT and the Neural Circuits of Anxiety — C&I only
To test whether specific neural circuitry changes, proposed on the basis of our neurocognitive model of anxiety, are a mechanism of action for CBT interventions.
Community Navigator Trial
Testing new ways to help people with treatment resistant depression who are also experiencing feelings of loneliness by increasing social inclusion in community. Closed for recruitment.
CONTACT-GAD - BEH only
To test the effectiveness of tailored ACT for reducing anxiety in older people with TR-GAD.
CoComp - C&I only
To identify potential neuro-cognitive mediators of psychotherapeutic interventions for depression. Closed for recruitment.
MATILDA — C&I only
To undertake a randomised feasibility study of the Matilda intervention to improve health, wellbeing and social networks of older adults with learning disability (LD). Closed for recruitment
PAX-D - C&I only
To evaluate the efficacy and mechanism of pramipexole (Parkinson’s medication) as add-on treatment for people with treatment resistant depression (TRD). Closed for recruitment.
Social Brain - C&I only
Looking at the social brain and decision-making skills in people seeking CBT for psychological difficulties.
To evaluate the efficacy and mechanism of pramipexole (Parkinson’s medication) as add-on treatment for people with treatment resistant depression (TRD). Closed for recruitment.
Social Brain - C&I only
Looking at the social brain and decision-making skills in people seeking CBT for psychological difficulties.
ADHD and Learning Disabilities Research
ART-CARMA - BEH only
The study of cardiometabolic risk factors and medication adherence in people with ADHD. Closed for recruitment.
PETAL
To develop a personalised treatment package for aggressive challenging behaviour in people with Learning Disabilities.
Bipolar Disorder Research
ASCEnD - C&I only
To examine the clinical and cost-effectiveness of Aripiprazole/sertraline combination in comparison with quetiapine for the treatment of bipolar depression.
Children, Adolescent and Young People Research
ERiC
To evaluate the clinical utility of Mentalization Based Treatment (MBT) for children with mixed emotional and behavioural difficulties.
Wellbeing While Waiting
To evaluate the effectiveness of social prescribing in CAMHS.
Dementia Research
SOCIAL — C&I only
Exploring impairment in theory of mind associated with decline in social functioning in Alzheimer's disease
Addictions Research
FORWARDS 2
To evaluate feasibility and determine if baclofen shows potential efficacy in facilitating detoxification from methadone in community-based opiate dependent participants
Routine Screening for Gambling-related Harm
To evaluate how feasible it is to introduce a short screening questionnaire for gambling-related harm in mental health and drug and alcohol services.
Intervention Research
ASsuRED
Improving outcomes in patients who self-harm by adapting and evaluating a brief Psychological Intervention in Emergency Departments.
DIAMONDS
To develop and test a self-management intervention that can specifically jelp people with Type II Diabetes and Serious Mental Illness
Finch - C&I only
To develop and test an intervention to prevent compulsory readmission and develop self-management skills among people who have been compulsorily detained under the Mental Health Act.
moreRESPECT
To trial an intervention designed to promote sexual health for people with severe mental illnesses and to assess its clinical and cost effectiveness.
ERiC - BEH only
To evaluate the clinical utility of Mentalization Based Treatment (MBT) for children with mixed emotional and behavioural difficulties.
Psychosis Research
ADEPP - C&I only
To establish the effectiveness and cost-effectiveness of an antidepressant medication (sertraline) for the prevention of a depressive episode following first episode psychosis (FEP).
CLEAR
To test the effectiveness of clozapine in treatment-resistant early psychosis in people aged 12 to under 25.
CNNP - BEH only
To understand the neurocognitive aspects of people with a psychotic disorder.
To understand the neurocognitive aspects of people with a psychotic disorder.
NIMPsy — C&I only
To understand neural ciruits and immunity in psychosis, and demonstrate a causal role for immune dysregulation in psychosis.
PIPP2
To establish the prevalence of neuronal cell surface antibodies in people with psychosis.
RADAR Follow-up
A long-term follow-up study investigating the effect of reduction and discontinuation of antipsychotic medication.
To establish the prevalence of neuronal cell surface antibodies in people with psychosis.
RADAR Follow-up
A long-term follow-up study investigating the effect of reduction and discontinuation of antipsychotic medication.
Genetic Testing Research
GLAD
To explore genetic predictors of depression and anxiety disorders.
Pharmacogentics in Mental Health - C&I only
To see if genetic testing could be useful for patients who are going to be given psychiatric drugs as treatment for their mental illness.
